Overview
We are seeking a highly motivated candidate to join our Computational Structural Biology group. The candidate will employ state-of-the-art AI-based protein design methods and advanced molecular dynamics simulations to support the design of enhanced enzymes used as therapies for lysosomal storage disorders (LSD). This project aims to overcome the main limitations of current LSD therapies by improving the potency of the enzyme, reducing the doses required, and minimizing the side effects. This contract is intended to prepare the candidate for a potential transition into a PhD program. This is a full-time in-person position at the Telethon Institute of Genetics and Medicine (TIGEM), located in Pozzuoli, Naples, Italy.
* Experience with the Python programming language and Linux-based operating systems
* Familiarity with biomolecular simulations and/or familiarity with machine learning/deep learning methods
* Master’s degree in physics, chemistry, biology, computer science, or a related field
* High motivation and willingness to work in an interdisciplinary and collaborative environment
Desirable (but not essential)
* Previous experience with AI-based protein design/modelling algorithms (e.g., ProteinMPNN, ESM, Rosetta, etc.)
* Previous experience with GROMACS or other MD software
#J-18808-Ljbffr