University
Vita‑Salute San Raffaele University, Milan, Italy.
Fields
Biology, Molecular Biology, Biomedical Sciences, Genetics, Physiology.
About the University
Vita‑Salute San Raffaele University, based in Milan, Italy, is a renowned institution recognized for its excellence in medical and scientific research. The university is affiliated with the prestigious San Raffaele Hospital, one of Europe’s leading centres for biomedical research, clinical care, and education. The academic environment fosters interdisciplinary collaboration, innovation, and a commitment to translating scientific discoveries into clinical applications.
Research Topic and Significance
The project focuses on developing innovative therapeutic approaches for muscular dystrophies, with particular emphasis on LAMA2‑related muscular dystrophy (LAMA2‑RD). The central aim is to elucidate the role of fusogenic transmembrane proteins Mymk and Mymx in skeletal muscle homeostasis and regeneration. Dysregulation of these proteins has been implicated in impaired muscle regeneration, increased apoptosis, and tissue atrophy in dystrophic conditions. By understanding the molecular and cellular pathways involved, this research has the potential to pave the way for novel interventions that could improve outcomes for patients suffering from these debilitating disorders. The project’s translational nature underscores its significance in both basic science and clinical application.
Project Details
* Design and perform in vitro experiments using dystrophic satellite cells and myofibres.
* Conduct in vivo studies utilizing mouse models, specifically those with complete Laminin‑211 deficiency.
* Manipulate gene expression through overexpression, knockdown, and fine‑regulation strategies at various developmental stages.
* Analyse molecular and cellular pathways related to cell‑cycle regulation, apoptosis, and muscle regeneration.
* Perform transcriptomic and molecular data analysis.
* Contribute to manuscript preparation and dissemination of research findings.
* Maintain accurate and comprehensive records of all experimental results.
Candidate Profile
* A PhD in Biology, Molecular Biology, Biomedical Sciences, or a related discipline.
* Demonstrated experience in cell culture, molecular biology techniques, and gene‑expression analysis.
* Proficiency in working with mouse models and conducting in vivo experimental procedures.
* Strong ability to work both independently and as part of a collaborative research team.
* Creativity in scientific problem‑solving, flexibility in approach, and adaptability to evolving research priorities.
Application Process
Interested candidates should send their CV and a statement of interest to the address provided in the original LinkedIn post. For further information and application details, please refer to the LinkedIn advertisement: LinkedIn Post.
Conclusion
If you are ready to contribute to impactful research on muscular dystrophies and develop your career at a leading European biomedical institution, consider applying for this postdoctoral position.
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