Ph3Europe – Postdoctoral Position in Muscle Regeneration at Vita‑Salute San Raffaele University /h3 /brpAbout the University: Vita‑Salute San Raffaele University, based in Milan, Italy, is a renowned institution recognized for its excellence in medical and scientific research. The university is affiliated with the prestigious San Raffaele Hospital, one of Europe’s leading centres for biomedical research, clinical care, and education. The academic environment fosters interdisciplinary collaboration, innovation, and a commitment to translating scientific discoveries into clinical applications. /p /brpResearch Topic and Significance: The project focuses on developing innovative therapeutic approaches for muscular dystrophies, with particular emphasis on LAMA2‑related muscular dystrophy (LAMA2‑RD). The central aim is to elucidate the role of fusogenic transmembrane proteins Mymk and Mymx in skeletal muscle homeostasis and regeneration. Dysregulation of these proteins has been implicated in impaired muscle regeneration, increased apoptosis, and tissue atrophy in dystrophic conditions. By understanding the molecular and cellular pathways involved, this research has the potential to pave the way for novel interventions that could improve outcomes for patients suffering from these debilitating disorders. The project’s translational nature underscores its significance in both basic science and clinical application. /p /brh3Responsibilities /h3 /brul /brliDesign and perform in vitro experiments using dystrophic satellite cells and myofibres. /li /brliConduct in vivo studies utilizing mouse models, specifically those with complete Laminin‑211 deficiency. /li /brliManipulate gene expression through overexpression, knockdown, and fine‑regulation strategies at various developmental stages. /li /brliAnalyse molecular and cellular pathways related to cell‑cycle regulation, apoptosis, and muscle regeneration. /li /brliPerform transcriptomic and molecular data analysis. /li /brliContribute to research publications and presentations. /li /br /ul /p #J-18808-Ljbffr