PstronguAPPLICATION CLOSING DATE: August 31st 2025. /u /strong /ppHuman Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of five Centers: Computational Biology, Structural Biology, Genomics, Neurogenomics and Health Data Science. The Centers work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally. /ppbr/ppThe Human Technopole Foundation is looking for a Senior Bioinformatician in the lab of Prof. Giuseppe Testa, Neurogenomics Research Centre (aTesta Group - Human Technopole /a). The lab conforms its activity to the highest standards of reproducibility and transparency of the FAIR paradigm (Findable, Accessible, Interoperable and Reusable). It benefits from a state-of-the-art High-Performance Computing infrastructure, and from close interaction with an expert community of computational and experimental biologists and the transformative core facilities of HT, as well as computational support units such as the CEll REference BRain Atlas (CEREBRA) Scientific Support Units. /ppbr/ppbr/ppstrongSee previous work on the research topics of this call: /strong /ppCaporale, N. et al. Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single-cell resolution. strongNature Methods /strong 1–13 (2024). /ppBosone, C. et al. A polarized FGF8 source specifies frontotemporal signatures in spatially oriented cell populations of cortical assembloids. strongNature Methods /strong 1–13 (2024). /ppHe, Z. et al. An integrated transcriptomic cell atlas of human neural organoids. strongNature /strong 635, 690–698 (2024). /ppCaporale N, Leonardi O, Villa CE, Vitriolo A, Boeckx C, Testa G: Tile by tile: capturing the evolutionary mosaic of human conditions. strongCurr Opin Genet Dev /strong (2024), 90:102297. /ppLópez-Tobón, A. et al. GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders. strongScience Advances /strong 9, eadh2726 (2023). /ppCaporale, N. et al. From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures. strongScience /strong 375, eabe8244 (2022). /ppCheroni, C. et al. Benchmarking brain organoid recapitulation of fetal corticogenesis. strongTransl. Psychiatry /strong12, 520 (2022). /ppbr/ppbr/ppWe are looking for a highly-motivated strongSenior Bioinformatician /strong who will provide computational support for projects focused on the high definition modelling of neurodevelopmental disorders through the integration of brain organoid, technologies and a wide suite of multi-omic, imaging and functional assays. /ppbr/ppbr/ppstrongYour main tasks and responsibilities /strong: /pulliEstablishing and maintaining reproducible and well-documented bioinformatic pipelines for the standardised analysis of internal and external single cell multi-omics datasets. /liliSupporting researchers and collaborators by performing bioinformatic analysis and providing advice on the best suited statistical models. /liliDeveloping and maintaining computational analytical pipelines. /liliTesting and implementing innovative analysis tools from the international scientific community. /liliCollecting relevant internal and external single cell datasets and curate/harmonize their annotation and metadata. /liliContributing to the design and development of bespoke data portals and data navigation/visualization solutions. /liliCommunicating, explaining and contextualising statistical results to a wide variety of collaborators with varying degrees of statistical know-how. /liliMaintaining and documenting software, following best practices of software engineering (e.g., revisioning and containerization). /li /ulpbr/ppstrongRequirements /strong /ppbr/ppstrongMandatory requirements: /strong /pulliMSc in a quantitative field (bioinformatics, computer science, statistics, mathematics, physics, engineering or similar); /liliProficiency in at least one of the following programming languages: Python (preferable), R, java, javascript, C++, C#, MATLAB; /liliProficiency with code versioning systems (e.g., git, SVN) and familiarity with container technologies (e.g., Docker, Singularity, Podman); experience working in a Unix/Linux environment; /liliExperience in bioinformatics workflow systems (i.e., Nextflow, Snakemake, CWL); /liliFluency in English – HT is an international research institute /li /ulpbr/ppstrongPreferential requirements: /strong /pulliA PhD degree and/or years of work experience in a data science/software engineering related role; /liliPrevious experience in the analysis of single cell omics datasets and an interest in neurobiology (or previous experience in the field); /liliExpertise in the following areas: web frameworks for data visualization, dashboards, database, data management. /li /ulpbr/ppstrongOrganizational and social skills: /strong /pulliStrong organization skills and attention to detail; propensity to structure analytical steps in well-documented and reproducible workflows; /liliExcellent problem-solving, analytical and critical thinking skills; collaborative attitude and ability to work in teams with colleagues of heterogeneous scientific backgrounds; /liliAbility to manage competing priorities in a fast-paced environment and to work independently. /li /ulpbr/ppstrongApplication Instructions /strong /ppPlease apply online by sending: /ppi) a CV in English /ppii) a motivation letter in English /ppiii) names and contacts of 2 referees /ppFor any inquiry about the call, please feel free to contact Prof. Giuseppe Testa, (this email address should not be used to send applications). /ppbr/ppstrongWhy Human Technopole /strong /ppHT seeks scientific excellence, we recruit the best scientific talents through international, open calls. /ppOur working environment is international, friendly and inclusive. Our scientists work together across disciplines on research topics of biomedical relevance, leveraging synergies between their diverse skillsets and methodological approaches. /ppWe believe that highly diverse teams yield the best and most innovative results. /ppWe engage in outward-facing scientific activities aimed at benefiting the national and international research community. Training is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences and workshops. /ppbr/ppstrongMain benefits /strong /pulliWelfare plans. /liliCanteen service. /liliWork-life balance provisions. /liliItalian language training for foreigners. /liliMaternity leave up to 1 year and other support for new parents. /liliCounseling. /liliPossibility of flexible working hours /liliSupport for relocation. /liliTax benefits where applicable. /li /ulpbr/ppstrongSpecial consideration will be given to candidates who are part of the protected categories list, according to L. 68/99. /strong /ppbr/ppstrongNumber of positions offered: 1 /strong /ppstrongLocation: /strongMilan /ppstrongContract offered: /strong CCNL Chimico Farmaceutico, Employee level, 3 years fixed-term. /ppstrongSalary: /strongup to 48k. /ppbr/ppemThe Foundation reserves the right, at its sole discretion, to extend, suspend, modify, revoke, or cancel this job posting without giving rise to any rights or claims whatsoever in favour of the candidates; the Foundation reserves, however, the right not to proceed with the awarding of the above-described assignment due to the effect of supervening regulatory provisions and/or obstructive circumstances. /em /p