Pubblicato il 17 giugno
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PpProfessional | Permanent | Full-time | Hybrid /p pIf you’re passionate about changing lives for the better, this is the opportunity you’ve been waiting for. In bResearch Development /b, we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state-of-the-art Research Development environment, developing innovative medicines that change the life of patients for the better and help us make progress towards our vision of a world free of pain. Join us today, and discover the difference you can make. /p h3What The Job Looks Like /h3 ul liLead the design and computational optimisation of RNA therapeutics, particularly siRNA, integrating RNA biology with oligonucleotide chemistry to enable gene knockdown and RNA regulatory approaches, including up-regulation strategies. /li liDefine and prioritise target sites and design strategies by integrating sequence features, RNA accessibility, transcript structure, cross-species alignment, and emerging experimental data. /li liDrive iterative design–test–learn cycles by analysing and rapidly integrating datasets linking sequence, chemistry, and biological activity to inform decision-making. /li liDevelop and apply computational tools and workflows (e.g. Python or R) to enable scalable oligonucleotide design, data integration, and rapid sequence–chemistry iteration. /li liPartner closely with oligonucleotide chemists and delivery scientists to co‑optimise sequence, chemical modifications, and delivery approaches to maximise potency, durability, and tissue activity. /li liLead and contribute to discovery programs advancing RNA therapeutic candidates toward candidate profiling and clinical development, while helping prioritise and evaluate new targets aligned with platform capabilities. /li /ul h3What You’ll Bring To The Table /h3 ul liPhD in RNA biology, molecular biology, computational biology, bioinformatics, or a related discipline. /li liMore than 10 years of relevant industry experience, including at least 5 years in therapeutic antisense or siRNA design and optimisation. /li liStrong computational skills, including experience developing scripts or workflows (e.g. Python or R). /li liExperience designing siRNA across CNS and systemic delivery contexts, including optimisation of sequence and chemistry for robust in vivo activity. /li liProven track record contributing to or leading programs that progressed molecules to candidate stage, with demonstrated involvement in programs advancing toward clinical development. /li liStrong understanding of oligonucleotide optimisation and risk assessment across discovery and development stages, from early design through to late‑stage candidate selection. /li liExperience delivering siRNA therapeutics in liver and CNS indications is highly desirable, ideally including progression of molecules toward clinical development. /li liStrong scientific problem‑solving mindset with a focus on delivering impact. /li liAbility to operate effectively in a highly matrixed, cross‑functional environment with a high degree of independence, ownership, and accountability. /li /ul pBe part of a team redefining what’s possible in genetic medicine, creating transformative RNA therapies for severe pain, neurological disease, and adjacent areas where we can extend the reach of our platforms. /p pKeith Geoffrey Phillips , the Hiring Manager /p /p #J-18808-Ljbffr
