PFIS is a leading Italian company and one of the top players in Europe in the development and production of Active Pharmaceutical Ingredients (APIs) for the global pharmaceutical industry. With three production plants and more than 2.300 employees, for almost 70 years we have focused on research, quality, and sustainability. /ppFIS products improve the lives of millions of people: a responsibility we face with pride and passion. Join the team and become part of a company growing thanks to the commitment of those who live it every day. /ppbr/ppWe are looking for a bExpert in high-pressure chromatography /b with a strong background in bpeptide /b bpurification /band bprocess scale-up /b. The ideal candidate has several years of hands-on experience developing, optimizing, and implementing robust purification methods from RD to large-scale, including GMP manufacturing environments. This role requires deep technical expertise, problem-solving ability, and the capacity to work cross-functionally with RD, process development, manufacturing, and quality teams. /ppbr/ppbKey Responsibilities /b /pulliDevelop and optimize chromatographic purification methods for synthetic peptides using high-pressure systems (Reverse Phase-HPLC) and other ancillary technologies (Ion Exchange, Size Esclusion Chromatography); /liliScale purification processes from lab to pilot and production scale, ensuring robustness, reproducibility, and regulatory compliance; /liliSelect, configure, and validate chromatographic equipment, columns, resins, and system parameters; /liliDesign and execute experiments to evaluate critical process parameters and performance attributes; /liliTroubleshoot complex purification challenges, including impurities, yield loss, peak splitting, column degradation, and pressure limitations; /liliImplement process control strategies and participate in tech transfer to manufacturing; /liliSupport process characterization, validation, and documentation (SOPs, batch records, development reports); /liliWork closely with analytical, upstream/solid-phase synthesis, and formulation teams to ensure seamless integration along the peptide production workflow; /liliStay current with emerging technologies and approaches in chromatography and peptide purification. /li /ulpbr/ppbRequired Qualifications /b /pulliAdvanced degree (PhD or MSc) in Chemistry, Analytical Chemistry, Industrial Chemistry, Chemical Engineering, or related disciplines; /lili5–10+ years of hands-on experience with high-pressure chromatography applied to peptide purification; /liliDemonstrated expertise with method development, process optimization, and scale-up for preparative HPLC; /liliStrong knowledge of column chemistry, stationary phases, pressure limits, and peptide behavior under chromatographic conditions; /liliExperience in purification at pilot and manufacturing scale, ideally in a regulated environment (GMP preferred); /liliProficiency in chromatographic software and method modeling tools; /liliExcellent troubleshooting, documentation, and communication skills; /liliKnowledge of downstream unit operations beyond chromatography (ultrafiltration/diafiltration, lyophilization, crystallization). /li /ulpbr/ppbPreferred Experience /b /pulliIndustrial experience in peptide therapeutics, CDMO, or specialty chemicals; /liliFamiliarity with continuous chromatography, simulated moving bed systems, or preparative UPLC. /li /ulpbr/ppbKey Competencies /b /pulliStrong technical leadership and ownership of purification workflows; /liliAbility to design experiments and interpret complex data rapidly; /liliCross-functional collaboration and mentoring of junior scientists; /liliQuality-minded, detail-oriented, and comfortable in a fast-paced environment. /li /ulpbr/ppbOffice location /b /ppFIS Head Quarters is located in Montecchio Maggiore (Vicenza). /p