P We are seeking a Researcher in Computational Genomics and Multi-Omics Integration to develop novel methodologies for investigating glioma heterogeneity joining the CTGLab. /p p Feel free to contact us if you are curious to know more. Please use the email address: /p pu Duration /u : 1 year (renewable) /ppu Project /u : TRANSCAN-3 SeqPerGlio /ppu Location /u : CTGLab, IIT-CNR, Pisa-Siena, Italy /ppu Start Date: /u (To be determined) /p p⚠️ The present announcement does not constitute a formal recruitment procedure, but rather a scouting initiative to identify profiles of interest. Candidates will be invited to apply through an official public competition/bando. /p pb Overview /b /pp The Computational and Translational Genomics Laboratory (CTGLab) at IIT-CNR, Pisa-Siena, Italy, is seeking a highly motivated Postdoctoral Researcher in Computational Genomics to join our team working on the TRANSCAN-3 SeqPerGlio project: "Intraoperative tumour sequencing for personalized loco-regional drug combination therapy against glioblastoma recurrences". /pp The position offers a unique opportunity to work at the intersection of cutting-edge computational innovation and direct clinical translation in precision neuro-oncology. The successful candidate will develop novel computational methodologies for real-time genomic and epigenomic profiling using Oxford Nanopore Technologies (ONT) long-read sequencing, contributing to personalized treatment strategies for glioblastoma patients. /p pb Project Description /b /pp SeqPerGlio is an international TRANSCAN-3 consortium project ) focused on establishing intraoperative molecular profiling workflows to guide personalized drug combination therapy for glioblastoma. The project integrates: /pp- Real-time nanopore sequencing of tumor specimens during surgery /pp- Multi-omics data integration (genomics, transcriptomics, epigenomics) /pp- Clinical decision support for loco-regional therapy selection /pp- Direct collaboration with neurosurgery centers across Europe /p pb Responsibilities /b /pp Design and implement computational pipelines for real-time analysis of Oxford Nanopore long-read sequencing data, including: /pulli Structural variant detection and clonality assessment /lili DNA methylation profiling and tumor classification /lili RNA isoform analysis and fusion detection /lili Integration with clinical genomic databases /li /ulp Develop novel algorithms for: /pulli Rapid quality control and data processing optimized for clinical timelines /lili Multi-omics data integration from nanopore, single-cell, and imaging data /lili Biomarker identification for therapy response prediction /lili Tumor heterogeneity characterization /li /ulp Collaborate closely with wet-lab scientists, clinicians, and neurosurgeons to: /pulli Translate computational results into actionable clinical insights /lili Establish validation protocols and quality metrics /lili Contribute to standard operating procedures for clinical implementation /li /ulp Contribute to scientific dissemination through publications in high-impact journals, presentations at international conferences, and consortium reports /p p CTGLab is a multidisciplinary team specializing in computational methods for multi-omics integration in cancer genomics. For details on research activities and latest publications, visit the /p pb Application Process /b /pp Interested candidates are invited to provide: /pp1. cv including publication list /pp2. Cover letter describing research interests, relevant experience, and motivation for applying (max 2 pages) /pp3. Contact information for two academic references /p p Applications will be reviewed on a rolling basis. /p