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Scientist i, process and analytical development

Monza
Thermo Fisher Scientific
Pubblicato il 9 febbraio
Descrizione

Responsibilities: - Develop and implement scalable mRNA purification strategies, to generate highly pure material. - Design, develop, and implement workflows for mRNA production. - Uses a data-driven approach to progress development deliverables. - Develop robust and scalable downstream processes at the laboratory scale for the purification of nucleic acids with tangential flow filtration and liquid chromatography. - Perform troubleshooting process performance issues. - Support scale-up of upstream/downstream processes and technology transfer to the cGMP manufacturing and quality control groups for clinical material production. - Perform routine bench work under limited supervision, effectively prioritize responsibilities and complete assignments in a timely manner. - Able to analyze, interpret, and present results to project teams and write technical reports. - Maintaining domain expertise in new technologies and scientific literature to constantly drive innovation. Qualifications: Requirements: - Demonstrated experience with standard analytical equipment (plate reader, nanodrop, spectrophotometer, PCR, protein and nucleic acid electrophoresis) and knowledge of molecular biology, biochemistry, and biophysics protocols is required. - Strong technical expertise in two or more of the following: in vitro transcription (IVT) synthesis, molecular cloning, capillary gel electrophoresis (CGE) high-performance liquid chromatography (HPLC), fast protein liquid chromatography (FPLC), and tangential flow filtration (TFF). - Experience in upstream processing, including use of bioreactors at small, intermediate, and large scales; familiarity with the process development of mRNA products would be a plus. - Experience writing content for technical documentation, including SOPs, work instructions, technical protocols and reports, and technical presentations. - A high level of commitment and a track record of quality work, with attention to detail. - Capable of communicating the work clearly among the team - A self-starter and great teammate.

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