PpbSite Name: /b USA - Massachusetts - Cambridge, Belgium-Rixensart, Italy - Siena, Upper Providence /ppbPosted Date: /b Jan /ppThe bDirector, Head of Computational Design /b is accountable for the design and application of new advanced computational methods, including Large Language Models (LLMs) and AI, for cutting-edge mRNA design and next-generation vaccine and platform design and development. /ppThis role guides the design and optimization of nucleic acid therapeutics (e.g., mRNA), associated vaccine platforms (e.g., vaccines, antigens, multiple antigens presenting systems, and adjuvants) and delivery systems (LNPs). /ppProviding innovative in silico solutions — encompassing structural bioinformatics, molecular modeling, and AI/ML-driven design — this role integrates active learning into Discovery Technology workflows to enhance immunogenicity, efficacy, and stability. This role supports discovery and preclinical research, translational, and early clinical stages as requested by DPLs, VDLs, PILs, and clinical sciences teams. /ppThe Head leads and mentors a world-class team, ensuring scientific excellence, strategic alignment with the Head of VIDRU Data Sciences and VIDRU RD project/platform leaders, and adherence to top scientific and industry standards for all deliverables. /ph3What You’ll Do /h3ulliProvides strategic vision and leadership for computational molecular design initiatives within VIDRU Data Sciences, with a primary focus on next generation mRNA design, vaccine, antigen and NLP platform development. /liliLeads and manages a multidisciplinary team of computational design scientists, fostering a culture of high performance, scientific innovation, and continuous professional development. /liliDirects the development and application of advanced computational design methodologies, including structural bioinformatics, molecular modeling, and protein/nucleic acid engineering, with a strong emphasis on mRNA sequence and structure optimization. /liliDrives the leveraging of AI and LLMs for de novo design, optimization, and predictive modeling (e.g., molecular stability, protein expression, immunogenicity) of antigens, mRNA, LNPs, adjuvants, and monoclonal antibodies/ADCs. /liliEnsures scientific integration by embedding computational design experts within discovery project teams, providing critical data science expertise from early-stage research through candidate selection and optimization, particularly for mRNA and platform-specific data. /liliIntegrates computational predictions with experimental validation via active learning loops, establishing strong links with DiscoTech laboratories to accelerate iterative molecule design and optimization cycles. /liliEstablishes strong collaborative links with DPLs, VDLs, PILs, TPLs and clinical sciences teams to ensure computational design insights directly inform and accelerate pipeline progression. /liliDrives innovation in computational design analytics by partnering closely with GSK's AIML and RD Tech divisions, and external academic/industry Key Opinion Leaders, exploring and integrating novel AI/ML methods and computational paradigms. /li /ulh3Basic Qualifications /h3ulliPhD or equivalent experience. Computational Biology, Data Science, Mathematics and Physics, Biological or Chemical Engineering, Bioinformatics, Computational Life Sciences or equivalent. /liliIn depth theoretical background and practical experience on quantitative sciences applied to biology and strong competences in computer science. /liliResearch experience and publication record in one or more of the relevant areas of expertise. /lili8+ yrs in scientific experience, including four years of direct/matrix people management and international leadership responsibilities (e.g. principal investigator for international RD projects in relevant areas). /liliProven capacity to use the theoretical background and education to solve actual problems of RD projects working and leading teams in cross-functional setting. This role shall act as a global reference person for the function and perform people management and coaching of global staff. /li /ulh3Preferred Qualifications /h3ulliDemonstrated strong proficiency / publication record in one or more of the following areas: /liliAdvanced molecular modelling and simulation (e.g., molecular dynamics, docking, free energy calculations). /liliStructural bioinformatics and protein engineering for antigen/vaccine design. /liliLeading application of AI and LLMs for de novo mRNA design, optimization of mRNA sequence and structure, and predictive modelling for mRNA-based therapeutics. /liliComputational design of nucleic acid-based therapeutics (e.g., mRNA, viral vectors) and their delivery platforms (e.g., LNPs). /liliPredictive modelling for molecular stability, protein expression, and immunogenicity. /liliChemoinformatic and rational drug design principles. /liliHigh-performance scientific computing infrastructures for large-scale computational design projects. /liliExperience with active learning frameworks for experimental design and optimization. /li /ulp#GSK-LI /ppbSalary note: /b If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $178,200 to $297,000. If you are based in another US location, the annual base salary range is $0 to $0. The US salary ranges take into account factors including work location, candidate skills, experience, education level and market rate. This position offers an annual bonus and eligibility to participate in our share-based long-term incentive program. Available benefits include health care and other insurance benefits, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process. /ppPlease visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. /ph3Why GSK? /h3pUniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale. /ppPeople and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people. /ppShould you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at where you can also request a call. /ppPlease note should your inquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receive /ppGSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. /ppImportant notice to Employment businesses/ Agencies. GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. /ppPlease note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at /p /p #J-18808-Ljbffr