Human Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of five Centers : Neurogenomics, Computational Biology, Structural Biology, Genomics, and Health Data Science. The Centers work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.
The Human Technopole Foundation is looking for a Technician / Senior Technician for a maternity cover (possible starting date in September), to work in the group of Prof. Giuseppe Testa, Neurogenomics Research Centre (Testa Group - Human Technopole).
About the lab :
We focus on the dynamics of brain disorders, with a strong emphasis on human experimental models and straddling multiple scales of analysis from single cell resolution to organismal function, working in close integration with national and international deeply phenotyped cohorts that provide unique edges for the study of gene / environment interactions in mental health vulnerability and resilience. Our lab has developed a unique ecosystem characterized by the systematic integration of wet and dry research flows to foster an authentic culture of hybridity that transgresses experimental / computational divides. Our research environment includes transformative facilities encompassing reprogramming, editing and brain organoids automation, state of the art genomics and microscopy infrastructures along with a HT-wide architecture of high performance computing (HPC) attuned to the needs of contemporary computational biology.
See previous work on the research topics of this call :
Caporale, N. et al. Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single-cell resolution. Nature Methods 1–13 (2024).
Bosone, C. et al. A polarized FGF8 source specifies frontotemporal signatures in spatially oriented cell populations of cortical assembloids. Nature Methods 1–13 (2024).
He, Z. et al. An integrated transcriptomic cell atlas of human neural organoids. Nature 635, 690–698 (2024).
Caporale N, Leonardi O, Villa CE, Vitriolo A, Boeckx C, Testa G : Tile by tile : capturing the evolutionary mosaic of human conditions. Curr Opin Genet Dev (2024), 90 : 102297.
Caporale, N. et al. From cohorts to molecules : Adverse impacts of endocrine disrupting mixtures. Science 375, eabe8244 (2022).
Cheroni, C. et al. Benchmarking brain organoid recapitulation of fetal corticogenesis. Transl. Psychiatry 12, 520 (2022).
Key tasks and responsibilities :
Conducting experiments in the area of stem cell neurobiology, combining cutting-edge methods from molecular biology, genome editing, biochemistry, cell biology and organoids, genomics approaches, advanced imaging and high throughput / high content screenings.
Maintaining / generating / importing and optimizing experimental tools and protocols
Generating reliable data for publication in the projects to which s / he is assigned and record all data and results in specified forms (with Electronic Lab Notebooks)
Providing technical support and supervision to other laboratory members, including introduction and teaching of new laboratory techniques and support on the use of lab equipment to lab members.
Liaising with the Centre's Lab Manager and other staff to write risk assessments and ensure that they are regularly updated.
Maintaining cell lines generated and banked in the lab and ensure that all tissue culture users work according to health and safety guidelines and regulations.
Participating in key aspects of general lab management and organization (e.g., managing inventories and stocks of samples, reagents, equipment, and materials), in coordination with HT facilities and service units.
Essential requirements :
Master's degree in relevant field (i.e. neuroscience, genetics, molecular biology, biotechnology)
Working knowledge of cell culture
Knowledge of molecular biology techniques
Fluency in English – HT is an international institute
Preferred requirements :
MD or PhD
Academic experience with brain organoids
Academic experience with pluripotent stem cells
Knowledge of Automation and Data Analysis
Organizational and social skills :
Strong organizational abilities
Team-working attitude
Application Instructions
To apply, please send the following :
a CV.
a motivation letter in English relating your track record to the specifics of the call.
names and contacts of 2 referees.
Why Human Technopole :
HT seeksscientific excellence, we recruit the best scientific talents through international, open calls.
Our working environment isinternational,friendlyandinclusive. Our scientistswork together across disciplineson research topics of biomedical relevance,leveraging synergiesbetween their diverse skillsets and methodological approaches.
We believe thathighly diverse teams yield the best and most innovative results.
We engage inoutward-facing scientific activitiesaimed at benefiting the national and internationalresearch community.Training is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences and workshops.
Work-life balance provisions.
Italian language training for foreigners.
Parental leave up to 1 year and other support for new parents.
Researchers coming to Italy for the first time, or returning after residing abroad, benefit from very attractive income tax benefits.
Special consideration will be given to candidates who are part of the protected categories list, according to L. 68 / 99.
Number of positions offered : 1
Contract offered : CCNL Chimico Farmaceutico, maternity cover contract - Employee Level
Salary range : up to 41k, depending on the seniority of the candidate.
Tax benefits where applicable.
The position is based inMilan.
The Foundation reserves the right, at its sole discretion, to extend, suspend, modify, revoke, or cancel this job posting without giving rise to any rights or claims whatsoever in favor of the candidates; the Foundation reserves, however, the right not to proceed with the awarding of the above-described assignment due to the effect of supervening regulatory provisions and / or obstructive circumstances".
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