We are looking for a Pharmacology Scientist on behalf of an R&D company based near Milano.
The candidates need to have expertise in AAV-based gene therapy and Cellular Biology.
Main responsibilities :
* Prepares and maintains cell cultures (including primary cell cultures), perform studies and experiments including tissue processing, biochemical analyses, DNA, RNA and protein isolation, qRT-PCR, ELISA, immunoblot processing.
* Collaborate with cross-functional teams on planning in vitro and vivo screening campaigns in human osteoarthritis (OA) tissues and animal OA models.
* Develop, implement and execute in vitro screening assays, including binding assays and AAV transduction readouts in relevant cell lines.
* Perform bioanalysis for in vitro and in vivo studies to validate lead candidate capsids
* Collaborate with cross-functional teams on vector design, production, and payload optimization for developing engineered tissue-tropic AAV capsid variants.
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