UNIVERSITA' DEGLI STUDI DI URBINO CARLO BOOrganisation / Company UNIVERSITA' DEGLI STUDI DI URBINO CARLO BO Department Department of Biomolecular Sciences (DISB) Laboratory Computer-Assisted Molecular Design (CAMD) Is the Hosting related to staff position within a Research Infrastructure? NoAre you looking to take the next step in your research career and contribute to advances in computational polypharmacology?The Computer-Assisted Molecular Design (CAMD) Lab at the University of Urbino Carlo Bo is seeking talented researchers to collaborate on projects at the interface of computational chemistry, biophysics, and drug discovery. The CAMD Lab is involved in several drug discovery campaigns focused on the identification of multitarget ligands. These projects address widely studied protein families, including kinases and GPCRs, as well as disease-relevant targets.Our in silico approaches include classical molecular docking, tailored library design, and AI-driven data analysis.Recent work has led to the development of dual-target compounds with activity in nicotine addiction and bipolar disorder.Building on our established expertise in molecular modelling, simulation methods, and machine learning, we are seeking to strengthen the lab’s experimental dimension through this call, in particular by integrating biophysical and related analytical approaches into our multitarget drug discovery strategies.The selected candidate will work under the supervision of Prof. Giovanni Bottegoni, Professor of Medicinal Chemistry at the University of Urbino and Honorary Senior Research Fellow at the University of Birmingham, with experience in both academia and industry.Located in the UNESCO World Heritage city of Urbino, the University of Urbino Carlo Bo, founded in 1506, is a long-established institution with a strong international profile. The CAMD Lab is based at the recently renovated Enrico Mattei Campus, a modern research hub located three kilometres from the historic city centre.We invite interested researchers to apply for a Marie Skłodowska-Curie Actions Postdoctoral Fellowship (MSCA-PF) with the University of Urbino as host institution. The project will focus on the development of multitarget-directed ligands through the integration of computational and experimental approaches, combining molecular modelling with biophysical and analytical methods relevant to contemporary drug discovery. This is an opportunity to jointly develop a competitive MSCA-PF proposal and to carry out ambitious research in an internationally connected environment.This is an opportunity to:conduct high-level research in computational and experimental drug discovery;gain hands-on experience at the interface of biophysical, analytical, and computational methods;benefit from the facilities of the Enrico Mattei Campus, recently upgraded through major institutional investment;receive full support in the development of a competitive MSCA-PF application;join a research group with an international profile and strong links with industry and academia.Eligibility criteriaApplicants must hold a PhD or have successfully defended their PhD before the MSCA-PF call deadline (9 September 2026).Applicants must have no more than eight years of full-time research experience after the PhD.Applicants must not have resided or carried out their main activity in Italy for more than 12 months in the 36 months preceding the EU call deadline.Applicants must be willing to relocate to Urbino, Italy.Applicants of any nationality are welcome.Candidate profileWe seek applicants with a documented experimental background in drug discovery, with hands‑on expertise in one or more relevant biophysical or analytical techniques, such as surface plasmon resonance (SPR), microscale thermophoresis (MST), biolayer interferometry (BLI), circular dichroism (CD), NMR-based screening, mass spectrometry, or hydrogen-deuterium exchange (HDX). Candidates should also be interested in developing first-hand experience in computational drug discovery. Because a competitive MSCA Postdoctoral Fellowship proposal depends on clear two-way knowledge exchange between candidate and host, applicants must bring established expertise in at least one relevant experimental method. Applications from candidates with a purely or predominantly computational background will normally not be taken forward.Interested candidates should email camd@uniurb.it with the subject line “MSCA 2026 Expression of Interest – [Name]” and include:a CV;one or two letters of support (optional).Deadline for applications30 April 2026We are committed to fostering an inclusive, diverse, and equitable research environment. We welcome applications from individuals of all personal backgrounds and encourage candidates from underrepresented groups to apply.ContactProf. Giovanni BottegoniDepartment of Biomolecular SciencesUniversity of Urbino Carlo BoEmail: camd@uniurb.itWeb: camd.uniurb.it
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